Clinical predictors of mortality of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection: A cohort study
Identifieur interne : 000660 ( Main/Exploration ); précédent : 000659; suivant : 000661Clinical predictors of mortality of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection: A cohort study
Auteurs : Sarah H. Alfaraj [Arabie saoudite, Canada] ; Jaffar A. Al-Tawfiq [Arabie saoudite, États-Unis] ; Ayed Y. Assiri [Arabie saoudite] ; Nojoom A. Alzahrani [Arabie saoudite] ; Amal A. Alanazi [Arabie saoudite] ; Ziad A. Memish [Arabie saoudite, États-Unis]Source :
- Travel Medicine and Infectious Disease [ 1477-8939 ] ; 2019.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Arabie saoudite (épidémiologie), Centres de soins tertiaires, Coronavirus du syndrome respiratoire du Moyen-Orient, Facteurs de l'âge, Femelle, Hormones corticosurrénaliennes (effets indésirables), Hormones corticosurrénaliennes (usage thérapeutique), Humains, Infections à coronavirus (), Infections à coronavirus (mortalité), Infections à coronavirus (épidémiologie), Mâle, Numération formule sanguine, Sérumalbumine, Traitement substitutif de l'insuffisance rénale (effets indésirables), Études de cohortes, Études rétrospectives.
- MESH :
- effets indésirables : Hormones corticosurrénaliennes, Traitement substitutif de l'insuffisance rénale.
- mortalité : Infections à coronavirus.
- usage thérapeutique : Hormones corticosurrénaliennes.
- épidémiologie : Arabie saoudite, Infections à coronavirus.
- Adulte, Adulte d'âge moyen, Centres de soins tertiaires, Coronavirus du syndrome respiratoire du Moyen-Orient, Facteurs de l'âge, Femelle, Humains, Infections à coronavirus, Mâle, Numération formule sanguine, Sérumalbumine, Études de cohortes, Études rétrospectives.
- Wicri :
- geographic : Arabie saoudite.
English descriptors
- KwdEn :
- Adrenal Cortex Hormones (adverse effects), Adrenal Cortex Hormones (therapeutic use), Adult, Age Factors, Blood Cell Count, Cohort Studies, Coronavirus Infections (epidemiology), Coronavirus Infections (mortality), Coronavirus Infections (therapy), Female, Humans, Male, Middle Aged, Middle East Respiratory Syndrome Coronavirus, Renal Replacement Therapy (adverse effects), Retrospective Studies, Saudi Arabia (epidemiology), Serum Albumin, Tertiary Care Centers.
- MESH :
- chemical , adverse effects : Adrenal Cortex Hormones.
- chemical , therapeutic use : Adrenal Cortex Hormones.
- geographic , epidemiology : Saudi Arabia.
- adverse effects : Renal Replacement Therapy.
- epidemiology : Coronavirus Infections.
- mortality : Coronavirus Infections.
- therapy : Coronavirus Infections.
- Adult, Age Factors, Blood Cell Count, Cohort Studies, Female, Humans, Male, Middle Aged, Middle East Respiratory Syndrome Coronavirus, Retrospective Studies, Serum Albumin, Tertiary Care Centers.
Abstract
Since the emergence of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in 2012, the virus had caused a high case fatality rate. The clinical presentation of MERS varied from asymptomatic to severe bilateral pneumonia, depending on the case definition and surveillance strategies. There are few studies examining the mortality predictors in this disease. In this study, we examined clinical predictors of mortality of Middle East Respiratory Syndrome (MERS) infection.
This is a retrospective analysis of symptomatic admitted patients to a large tertiary MERS-CoV center in Saudi Arabia over the period from April 2014 to March 2018. Clinical and laboratory data were collected and analysis was done using a binary regression model.
A total of 314 symptomatic MERS-CoV patients were included in the analysis, with a mean age of 48 (±17.3) years. Of these cases, 78 (24.8%) died. The following parameters were associated with increased mortality, age, WBC, neutrophil count, serum albumin level, use of a continuous renal replacement therapy (CRRT) and corticosteroid use. The odd ratio for mortality was highest for CRRT and corticosteroid use (4.95 and 3.85, respectively). The use of interferon-ribavirin was not associated with mortality in this cohort.
Several factors contributed to increased mortality in this cohort of MERS-CoV patients. Of these factors, the use of corticosteroid and CRRT were the most significant. Further studies are needed to evaluate whether these factors were a mark of severe disease or actual contributors to higher mortality.
Url:
DOI: 10.1016/j.tmaid.2019.03.004
PubMed: 30872071
PubMed Central: 7110962
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>Since the emergence of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in 2012, the virus had caused a high case fatality rate. The clinical presentation of MERS varied from asymptomatic to severe bilateral pneumonia, depending on the case definition and surveillance strategies. There are few studies examining the mortality predictors in this disease. In this study, we examined clinical predictors of mortality of Middle East Respiratory Syndrome (MERS) infection.</p>
</sec>
<sec><title>Methods</title>
<p>This is a retrospective analysis of symptomatic admitted patients to a large tertiary MERS-CoV center in Saudi Arabia over the period from April 2014 to March 2018. Clinical and laboratory data were collected and analysis was done using a binary regression model.</p>
</sec>
<sec><title>Results</title>
<p>A total of 314 symptomatic MERS-CoV patients were included in the analysis, with a mean age of 48 (±17.3) years. Of these cases, 78 (24.8%) died. The following parameters were associated with increased mortality, age, WBC, neutrophil count, serum albumin level, use of a continuous renal replacement therapy (CRRT) and corticosteroid use. The odd ratio for mortality was highest for CRRT and corticosteroid use (4.95 and 3.85, respectively). The use of interferon-ribavirin was not associated with mortality in this cohort.</p>
</sec>
<sec><title>Conclusion</title>
<p>Several factors contributed to increased mortality in this cohort of MERS-CoV patients. Of these factors, the use of corticosteroid and CRRT were the most significant. Further studies are needed to evaluate whether these factors were a mark of severe disease or actual contributors to higher mortality.</p>
</sec>
</div>
</front>
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</TEI>
<affiliations><list><country><li>Arabie saoudite</li>
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<region><li>Géorgie (États-Unis)</li>
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</affiliations>
</record>
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